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  • Title: Stem cell (CFUs) proliferation inhibitor in blood of mice injected with hydroxyurea.
    Author: Necas E.
    Journal: Cell Tissue Kinet; 1982 May; 15(3):263-8. PubMed ID: 7083297.
    Abstract:
    Analysis of the mouse haemopoietic stem cell (CFUs) kinetics after hydroxyurea administration has provided an in vivo assay suitable for detection of factors which inhibit recruitment of non-proliferating G0-CFUs into cell cycle, or transit of CFU's through the G1 phase. Using this assay, it has been demonstrated that plasma obtained from mice which had received hydroxyurea approximately 12-14 hr previously, possesses a factor which inhibited the triggering of CFUs into the cell cycle. The appearance of this CFUs proliferation inhibitor occurred at a time when 60-70% of the CFUs were synchronized in the S phase of the cell cycle, as a consequence of hydroxyurea action. Some basic properties of the inhibitor were investigated.
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