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  • Title: Q fever hepatitis: clinical manifestations and pathological findings.
    Author: Hofmann CE, Heaton JW.
    Journal: Gastroenterology; 1982 Aug; 83(2):474-9. PubMed ID: 7084625.
    Abstract:
    This report describes the clinical manifestations and pathological findings in 5 patients with serologically diagnosed acute Q fever. Each patient presented with headache, malaise, spiking fever, and hepatitis. Percutaneous biopsy of the liver in 4 patients revealed granulomatous changes with many lesions containing a dense fibrin ring surrounding a central lipid vacuole. Biopsy of the bone marrow in the fifth patient revealed similar abnormalities. These lipogranulomas should be considered characteristic of Q fever.
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