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  • Title: Arylamine N-methyltransferase. Methylation of the indole ring.
    Author: Lyon ES, Jakoby WB.
    Journal: J Biol Chem; 1982 Jul 10; 257(13):7531-5. PubMed ID: 7085637.
    Abstract:
    Arylamine N-methyltransferase catalyzes the novel methylation of the ring nitrogen of tryptamine and pyrrole as well as a number of other arylamines including aniline and its derivatives. S-Adenosyl-L-methionine serves as donor. Tyramine, indole, benzylamine, and desmethylimipramine were inactive as methyl group acceptors. The enzyme was purified from rabbit liver to electrophoretic homogeneity and was characterized as a protein monomer of 27,000 daltons with a pI of 4.8. The kinetic mechanism appears to be rapid equilibrium random Bi-Bi.
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