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  • Title: Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
    Author: Miller RC, Hall EJ.
    Journal: Br J Cancer; 1978 Sep; 38(3):411-7. PubMed ID: 708572.
    Abstract:
    The hypoxic cell sensitizer Misonidazole (Ro-07-0582) induces oncogenic transformations in the C3H/10T1/2 mouse embryo cell line cultured in vitro. A drug concentration of 0.4 mM applied to aerated cells for 3 or 6 days results in a transformation rate comparable to that observed following an X-ray dose of 1 Gray. A higher drug concentration of 6.0 mM is equivalent to 4 Gy. The combination of Misonidazole and X-rays produces a significant increase in the frequency of transformation over either drug or radiation alone, but the data are equivocal on the question of additivity vs synergism.
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