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  • Title: [Clinical studies of cefoxitin for the treatment of respiratory tract infections (author's transl)].
    Author: Suetsugu S, Naito T, Ishikawa H, Umeda H, Suzuki K, Morise M, Sakai S, Shimokata K, Katayama T, Kobayashi T, Tsunekawa H, Nishimura M, Iwakura M, Nishiwaki K, Nomura Y, Yoshikawa K, Fujii K, Izumi S, Katoh T, Ito T, Hattori J, Yoshii S, Takeura S, Maeda F.
    Journal: Jpn J Antibiot; 1982 Feb; 35(2):375-93. PubMed ID: 7087175.
    Abstract:
    A total of 42 patients who were suffering from respiratory tract infections were treated with cefoxitin, and the following results were obtained. 1. Out of 32 patients clinically evaluated, excellent or good responses were observed in 30 patients (94%). 2. Presumed causative organisms were isolated in 14 patients. The organisms were eradicated in 11 patients and the eradication rate was 79% (11/14). The number of the organisms decreased or unchanged in 1 patient each. In other 1 patient the pathogenic agent was replaced with other agents during the course of treatment. 3. As for the side effects, skin eruption was observed in 3 patients. One patient received drugs other than cefoxitin concomitantly that might have caused the eruption. Another patient had an allergic history to many antibiotics. In 4 patients slight elevations of S-GOT and S-GPT were observed but improved soon after the completion of cefoxitin treatment. In 1 patient an elevation of serum creatinine was observed but this was not attributed to the administration of cefoxitin. 4. From the results stated above, cefoxitin is considered to be a safe and effective antibiotic which can be one of the first-choice antibiotics for the treatment of respiratory tract infections.
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