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  • Title: [Reproduction study on netilmicin. (3) Perinatal and postnatal study in rats (author's transl)].
    Author: Furuhashi T, Nomura A, Tsujibayashi K, Nakayoshi H.
    Journal: Jpn J Antibiot; 1982 Feb; 35(2):643-58. PubMed ID: 7087183.
    Abstract:
    Perinatal and postnatal study on netilmicin (NTL), a new aminoglycoside antibiotic, was carried out in Sprague-Dawley rats (Slc : SD). NTL was administered intramuscularly from day 17 of gestation throughout day 20 after delivery at the daily dose of 12.5, 25, 50 and 100 mg/kg. Water intake of pregnant and nursing dams was increased in the animals treated with 50 mg/kg or more of NTL. The increase of cecum weight was observed in F1 animals in all treated groups at 3 weeks of age. However, birth rate, suckling rate, weanling rate, body weight, postnatal development, behavior and reproductive function remained within normal ranges in all treated groups.
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