These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Induction by X-rays of chromosomal aberrations in somatic and germ cells of mice with different karyotypes.
    Author: van Buul PP, de Boer P.
    Journal: Mutat Res; 1982 Feb 22; 92(1-2):229-41. PubMed ID: 7088004.
    Abstract:
    Stem-cell spermatogonia of +/+, T70H translocation heterozygous and Ts(1(13))70H tertiary trisomic mice were irradiated with various doses of x-rays. Blood lymphocytes of +/+ and Ts(1(13))70H males were irradiated with 150 rad X-rays. Contrary to earlier findings (De Boer et al., 1977), tertiary trisomic mice with morphological abnormalities did not show an increased sensitivity for radiation-induced chromosome breaks. The yields of radiation-induced reciprocal translocations, scored in the primary spermatocytes, were equal for the +/+ and tertiary trisomic mice but were lower for the T70/+ males. Thus, no parallel could be established with the sensitivity of peripheral blood lymphocytes for the induction of dicentric chromosomes, where T70H/+ did not differ from +/+ mice (De Boer et al., 1977). Induced reciprocal translocations occurred randomly over late diplotene-early diakinesis and late diakinesis-metaphase I stages. Among the T70H/+ males (2 x 500 rad) there was no relation between the chiasma frequency per animal and the yield of induced translocations, though the translocation induction was positively correlated with the chiasma frequency on a per-cell basis. When all descendants of irradiated T70H spermatogonia were pooled, the induced translocation-originated multivalent contained more chiasmata in cells that had a higher chiasma score themselves. No relation could be found between the yield of induced translocations and the recovery of spermatogenesis after irradiation as expressed by the epididymal sperm count after 2 x 500 rad.
    [Abstract] [Full Text] [Related] [New Search]