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  • Title: Development of clear cell adenocarcinoma in DES-exposed offspring under observation.
    Author: Kaufman RH, Korhonen MO, Strama T, Adam E, Kaplan A.
    Journal: Obstet Gynecol; 1982 Jun; 59(6 Suppl):68S-72S. PubMed ID: 7088431.
    Abstract:
    Two cases of clear cell adenocarcinoma of the vagina detected at follow-up in young women exposed in utero to diethylstilbestrol are reported. One patient, aged 23, had been followed for 2 years before carcinoma was diagnosed; the second patient, aged 22, had been seen on a regular basis for 5 years, 8 months. In both instances, suspicion of the presence of carcinoma was aroused by the palpation of a small nodule in the vaginal fornix. Hysterosalpingography was performed on both patients and, in 1 instance, an abnormal x-ray film was reflected by the gross appearance of the uterine cavity found in the surgical specimen.
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