These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Staphylococcal protein A and human IgG subclasses and allotypes.
    Author: Van Loghem E, Frangione B, Recht B, Franklin EC.
    Journal: Scand J Immunol; 1982 Mar; 15(3):275-8. PubMed ID: 7089488.
    Abstract:
    Staphylococcal protein A binds molecules belonging to the IgG1, IgG2, and IgG4 subclasses. IgG3 proteins generally do not bind, except for those coded by the two gamma 3 alleles, which are G3m(u-): G3m(b0,b3,b5,s,v). G3m(u) is located in the CH2 domain. The difference between G3m(u-) and G3m(u+) IgG3 proteins correlates with the sequence at position 339 in the CH2 domain--Ala and Thr respectively. There is another structural difference in the CH3 domain which correlates with protein A binding and non-binding: all IgG proteins that bind protein A have His at position 435, whereas those that do not, have Arg at that position.
    [Abstract] [Full Text] [Related] [New Search]