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  • Title: In vivo activation of zoxazolamine metabolism by flavone.
    Author: Lasker JM, Huang M-T, Conney AH.
    Journal: Science; 1982 Jun 25; 216(4553):1419-21. PubMed ID: 7089530.
    Abstract:
    The metabolism of zoxazolamine to 6-hydroxyzoxazolamine by liver microsomes from neonatal rats is stimulated severalfold by the in vitro addition of flavone, a naturally occurring compound found in several plant species. The intraperitoneal injection of flavone into neonatal rats causes an immediate several-fold stimulation in the rate of total body metabolism of simultaneously administered zoxazolamine. This is the first demonstration of stimulation of oxidative drug metabolism in vivo by a zenobiotic that is an activator of hepatic microsomal.
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