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  • Title: Prevention of thioacetamide-induced liver necrosis by prior aminoacetonitrile or imidazole administration.
    Author: De Ferreyra EC, De Fenos OM, Castro JA.
    Journal: Toxicol Lett; 1982 Apr; 11(1-2):55-9. PubMed ID: 7090016.
    Abstract:
    Prior administration of aminoacetonitrile (AAN) or imidazole but not isoxazole to rats, was able partially to prevent thioacetamide (TAC)-induced liver necrosis at 24 h. AAN and isoxazole did not prolong the pentobarbital sleeping time of the rats, while imidazole did. These and previous observations suggest a possible participation of non-cytochrome P-450 (P-450)-dependent aminoxidases in TAC activation to a necrogenic metabolite.
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