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  • Title: The use of labetalol in producing deliberate hypotension and its effects on intracranial pressure in dogs.
    Author: Van Aken H, Puchstein C, Hidding J.
    Journal: Acta Anaesthesiol Belg; 1982; 33(1):5-12. PubMed ID: 7090725.
    Abstract:
    The use of effective and safe hypotensive agents in neuroanesthesia is a difficult and unanswered question. Most hypotensive agents produce an increase in intracranial pressure and as a result can not be used until the dura is opened. In experiments in dogs, Labetalol, a combined alpha and beta-adrenoceptor antagonist, showed no increase in intracranial pressure and no change in intracranial compliance by producing hypotension.
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