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  • Title: Pneumococcal polysaccharide immunization of children with sickle cell disease. I. Clinical reactions to immunization and relationship to preimmunization antibody.
    Author: Overturf GD, Rigau-Perez JG, Selzer J, Field RJ, Powars D, Pang EJ, Uy C, Honig G, Weiss J, Chan L, Portnoy B.
    Journal: Am J Pediatr Hematol Oncol; 1982; 4(1):19-23. PubMed ID: 7091573.
    Abstract:
    Vaccine reaction data were obtained from 154 patients with sickle cell disease immunized with tetradecavalent pneumococcal polysaccharide vaccine. There was a high rate (70%) of mild reactions, primarily at the site of injection. Fever over 100 degrees F was uncommon and precipitation of symptoms similar to sickling crisis was rare. Development of local reactions was associated with the level of preimmunization pneumococcal antibody titer.
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