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  • Title: Nitrous oxide analgesia and altitude.
    Author: James MF, Manson ED, Dennett JE.
    Journal: Anaesthesia; 1982 Mar; 37(3):285-8. PubMed ID: 7091603.
    Abstract:
    The analgesic effectiveness of 50% nitrous oxide and oxygen or oxygen-enriched air, measured by variations in pain threshold, was studied at an altitude of 1460 m and simulated altitudes of sea level and 3300 m. At sea level pressures, 50% nitrous oxide exerted a similar analgesic effect to that found for morphine, raising the pain thresholds by a mean of 71.5%. At 1460 m, the increase in pain threshold produced was 40% and at 3300 m the increase in pain threshold was only 19%. The difference between the analgesic effects of nitrous oxide at each altitude was statistically significant. It is concluded that moderate altitudes significantly reduce the effectiveness of nitrous oxide in a manner directly related to the partial pressure of nitrous oxide at each altitude.
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