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  • Title: EFficacy of albendazole for treatment of naturally acquired fasciola hepatica in calves.
    Author: Malone JB, Smith PH, Loyacano AF, Hembry FG, Brock LT.
    Journal: Am J Vet Res; 1982 May; 43(5):879-81. PubMed ID: 7091853.
    Abstract:
    In calves given various doses of albendazole as a 4.55% (w/v) drench suspension, removal efficacies against mature Fasciola hepatica were 77.5% with the dose of 7.5 mg/kg; 92.3%, with 10 mg/kg; and 85.9%, with 15 mg/kg. Against immature F hepatica, drug efficacies with these doses were 32.7%, 20.0%, and 36.7%, respectively. Reductions in length and width measurements of mature and immature flukes recovered from the bile ducts correlated with the larger doses reflected a greater efficacy against mature flukes or a possible inhibiting effect of the drug on fluke size or growth. Numbers of eggs recovered in bile at necropsy were reduced by 87.8% with the dose of 7.5 mg/kg; 91.8%, with 10 mg/kg; and 95.6%, with 15 mg/kg.
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