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  • Title: Enhanced percutaneous penetration with 1-dodecylazacycloheptan-2-one.
    Author: Stoughton RB.
    Journal: Arch Dermatol; 1982 Jul; 118(7):474-7. PubMed ID: 7092271.
    Abstract:
    1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous absorption of a number of different chemicals. This report delineates the enhancement of penetration of clindamycin phosphate, erythromycin base, fusidate sodium, fluorouracil, desonide, amcinonide, and triamcinolone acetonide. For this purpose 1-dodecylazacycloheptan-2-one can be used in concentrations as low as 1%. It is colorless, relatively odorless, nontoxic, and can be applied neat to human skin without any irritation.
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