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  • Title: Renal haemodynamics after chronic treatment with labetalol and propranolol.
    Author: Malini PL, Strocchi E, Negroni S, Ambrosioni E, Magnani B.
    Journal: Br J Clin Pharmacol; 1982 Jun; 13(1 Suppl):123S-126S. PubMed ID: 7093095.
    Abstract:
    1 Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were measured in two groups of 12 patients both at rest and during sub-maximal cycloergometer exercise while on placebo and after 3 months of treatment with either labetalol or propranolol. 2 ERPF increased and renal vascular resistance decreased both at rest and during exercise after labetalol treatment, compared with placebo; the opposite was observed after propranolol treatment. 3 GFR increased after labetalol and decreased after propranolol both at rest and during exercise, compared with placebo, but these changes were not statistically significant. 4 Labetalol and propranolol resulted in the same decrease in blood pressure and a comparable incidence of side effects.
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