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  • Title: Cyclic AMP and allergic histamine release. Influence of methylxanthines on rat mast cells.
    Author: Norn S, Geisler A, Stahl Skov P, Klysner R.
    Journal: Acta Allergol; 1977 Jun; 32(3):183-91. PubMed ID: 70945.
    Abstract:
    Both isobutylmethylxanthine and theophylline increased the level of cyclic AMP in rat mast cells. Theophylline reduced the allergic histamine release, whereas isobutylmethylxanthine caused a pronounced potentiation of the histamine release. This indicates that the hypothesis of an inverse relationship between the level of cyclic AMP in mast cells and histamine release is inadequate.
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