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  • Title: Impaired serum antibody response to inactivated influenza A and B vaccine in cancer patients.
    Author: Stiver HG, Weinerman BH.
    Journal: Can Med Assoc J; 1978 Oct 07; 119(7):733,-5, 738. PubMed ID: 709474.
    Abstract:
    The serum antibody response to vaccination with bivalent inactivated influenza vaccine containing A/Port Chalmers/1/73 (H3N2) and B/Hong Kong/5/72 antigens was assessed in 44 patients with cancer and in 27 healthy control subjects. A fourfold or greater increase in antibody titre after vaccination occurred in 16 of the 44 cancer patients and 25 of the 27 controls for the A antigen, and in 14 of the 44 cancer patients and 20 of the 27 controls for the B antigen. Patients with lymphoma, who tended to have hypogammaglobulinemia, responded less well than did patients with solid tumours. Among the latter the failure to show a fourfold or greater increase in antibody titre correlated with a poorer 18-month survival.
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