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  • Title: Ophthalmologic toxicity after cis-dichlorodiammineplatinum(II) therapy.
    Author: Ostrow S, Hahn D, Wiernik PH, Richards RD.
    Journal: Cancer Treat Rep; 1978 Oct; 62(10):1591-4. PubMed ID: 709562.
    Abstract:
    Two cases of apparent ophthalmologic toxicity which occurred during treatment with cis-dichlorodiammineplatinum(II) (DDP) are described. In the first case, a patient with testicular carcinoma developed papilledema after three courses of DDP and adriamycin therapy. In the second case, a patient with breast cancer developed retrobulbar neuritis after three courses of DDP therapy. The differential diagnosis and possible explanation for these toxic effects are discussed.
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