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  • Title: Tryptophan analogues. 1. Synthesis and antihypertensive activity of positional isomers.
    Author: Safdy ME, Kurchacova E, Schut RN, Vidrio H, Hong E.
    Journal: J Med Chem; 1982 Jun; 25(6):723-30. PubMed ID: 7097726.
    Abstract:
    A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.
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