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  • Title: [Model substates and inhibitors of the peptidyltransferase center of ribosomes. Conformational possibilities in aqueous solution].
    Author: Diatkina NB, Kurochkin AV, Bobruskin ID, Florent'ev VL, Azhaev AV.
    Journal: Mol Biol (Mosk); 1982; 16(3):581-4. PubMed ID: 7099157.
    Abstract:
    The constants of sin-anti-equilibrium in aqueous solution of model inhibitors of peptidyltransferase center of ribosomes: 3'-amino-3'-deoxadenosine-5'-phosphate, 3'-N-glycinamido-3'-deoxyadenosine, 3'-(N-formyl-L-methionynamido)-3'-deoxyadenosine-5'-phosphate and 3'-(n-formylglycinamido)-3'-deoxyadenosine-5'-phosphate were determined using the measurements of spin-lattice relaxation times. All compounds have similar conformation possibilities of the nucleotide component. The possibilities of correlation between the biological activity of these compounds and their conformation in aqueous solution are discussed.
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