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  • Title: Prednisone treatment of non-nephrotic patients with idiopathic membranous nephropathy. A prospective study.
    Author: Kobayashi Y, Tateno S, Shigematsu H, Hiki Y.
    Journal: Nephron; 1982; 30(3):210-9. PubMed ID: 7099331.
    Abstract:
    18 adults with nonnephrotic proteinuria showed a milder form of idiopathic membranous nephropathy on renal biopsy. These patients were allocated to two groups, 2 years' steroid treatment or nontreatment. 8 of 9 tested patients showed complete disappearance of proteinuria in an average time of 2.4 months after starting the treatment, but in 9 patients of the nontreatment group proteinuria continued for at least 1 year. All five repeated biopsy specimens obtained after subsidence of proteinuria in the treatment group revealed a distinctive regression of glomerular basement membrane alterations. Though the study was not a controlled one, these results suggest that steroid therapy in idiopathic membranous nephropathy is beneficial, particularly in patients with lesser degrees of basement membrane lesions.
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