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  • Title: Immunity to coccidia in chickens: adoptive transfer with peripheral blood lymphocytes and spleen cells.
    Author: Rose ME, Hesketh P.
    Journal: Parasite Immunol; 1982 May; 4(3):171-85. PubMed ID: 7099704.
    Abstract:
    Suspensions of cells prepared from the caecal tonsils and spleen, and the peripheral blood lymphocytes of chickens immune to Eimeria maxima, were tested for their ability to transfer resistance to syngeneic recipients. The intravenous injection of approximately 6 x 10(8) spleen cells or peripheral blood lymphocytes caused a significant reduction of oocyst production by the challenged recipients, in comparison with controls which were uninjected or given cells from birds susceptible to E. maxima. Peripheral blood lymphocytes appeared to be most effective when obtained 10-15 days after a primary, or 3-10 days after a secondary inoculation of oocysts. The peripheral blood lymphocytes which participate in the early response to challenge of immune birds were not found to be protective. When given intraperitoneally, greater numbers of spleen cells were required to reduce oocyst production, and small numbers of caecal tonsil cells were ineffective. The ability of the various cell suspensions to transfer antibody and cell-mediated responses was monitored with 'marker' antigens. There was some indication that both types of response were involved in protection.
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