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  • Title: Effect of hydralazine on hepatic drug metabolizing enzymes in rats.
    Author: Hara S, Satoh T, Kitagawa H.
    Journal: Res Commun Chem Pathol Pharmacol; 1982 May; 36(2):260-72. PubMed ID: 7100630.
    Abstract:
    The effects of hydralazine on hepatic drug metabolizing enzymes were studied in rats. Hydralazine inhibited aminopyrine N-demethylase and aniline hydroxylase in vitro. Kinetic studies indicated that the inhibitory natures of hydralazine were recognized as almost mixed types and a change in difference spectrum demonstrated that hydralazine could bind to cytochrome P-450 as a characteristic type II. A single administration of hydralazine inhibited the drug metabolism, but neither reduction nor induction of the mixed function oxidase system were observed after the hydralazine treatment for 7 days, except the reduction of cytochrome b5 content. In addition, acidophilic degeneration and the formation of acidophilic bodies in liver cells by hydralazine were observed.
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