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  • Title: [Chromosome aberrations and sister chromatid exchanges in a human lymphocyte culture exposed to diethylstilbestrol dipropionate].
    Author: Dzhangulashvili NA.
    Journal: Tsitol Genet; 1982; 16(2):24-9. PubMed ID: 7101446.
    Abstract:
    Frequency of chromosome aberrations and sister chromatid exchanges (SCE) was studied in human lymphocyte culture treated with the synthetic nonsteroidal estrogen diethylstilbestrol-dipropionate in doses of 1.3 . 10(-7) M, 1.3 . 10(-6) M and 1.3 . 10(-5) M. Doses of 1.3 . 10(-6) M and 1.3 . 10(-5) M are shown to induce a significant increase in the chromosome aberration level mostly due to a rise in the number of polyploid cells. The same doses increase the frequency of SCE.
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