These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Cytotoxic drug treatment of lupus nephritis.
    Author: Donadio JV, Holley KE, Ilstrup DM.
    Journal: Am J Kidney Dis; 1982 Jul; 2(1 Suppl 1):178-81. PubMed ID: 7102666.
    Abstract:
    Patients with lupus glomerulonephritis improved after various combinations of azathioprine or cyclophosphamide and prednisone treatment in uncontrolled studies reported in the early 1970s. Later prospective clinical trials tested the effectiveness of these cytotoxic immunosuppressants. No important differences were found in clinical effects, serologic tests of lupus activity, renal function, and proteinuria when groups of patients treated with prednisone were compared with those treated with combined azathioprine prednisone or cyclophosphamide prednisone. There has been a two-fold increase in the 5-yr cumulative survival of patients with diffuse proliferative lupus nephritis in studies appearing after 1970 versus those published before 1970. However, the improved survival cannot be attributed to azathioprine or cyclophosphamide treatment.
    [Abstract] [Full Text] [Related] [New Search]