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  • Title: Effect of electroconvulsive shock on central cholinergic (muscarinic) receptors.
    Author: Gulati A, Nath C, Dhawan KN, Bhargava KP, Agarwal AK, Seth PK.
    Journal: Brain Res; 1982 May 27; 240(2):357-8. PubMed ID: 7104697.
    Abstract:
    Sensitivity of central cholinergic (muscarinic) receptors was studied in rats after application of single and repeated (once daily for 7 days) electroconvulsive shocks (ECS). Oxotremorine-induced tremor was significantly enhanced after single as well as chronic exposure to ECS; [3H]QNB binding in frontal cortex was also significantly increased by chronic ECS. The results indicate that ECS develops supersensitivity in central muscarinic receptors.
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