These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Unique cell surface glycoprotein expression in hairy cell leukemia: effect of phorbol ester tumor promoters on surface glycoproteins, cell morphology, and adherence.
    Author: Lockney MW, Golomb HM, Dawson G.
    Journal: Cancer Res; 1982 Sep; 42(9):3724-8. PubMed ID: 7105038.
    Abstract:
    Hairy cell leukemia cells from eight different patients exhibited a characteristic cell surface glycoprotein pattern when labeled by the neuraminidase-galactose oxidase-NaB3H4 procedure. The diffuse high-molecular-weight glycoprotein band (Mr 230,000 to 300,000) was not seen in other leukemic cell types and may represent a specific hairy cell leukemia antigen. Hairy cell leukemia cells can be maintained as cell suspension cultures, but treatment with a variety of tumor-promoting phorbol esters caused the cells to adhere to plates, assume a fibroblastic elongated shape, and extend long processes. This dramatic morphological change was not associated with any change in surface glycoproteins.
    [Abstract] [Full Text] [Related] [New Search]