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  • Title: The combined effects of oxygen tension, X radiation and 5-thio-D-glucose on the survival of mammalian cells.
    Author: Schulz RJ, Bongiorni P.
    Journal: Int J Radiat Oncol Biol Phys; 1982; 8(3-4):491-4. PubMed ID: 7107373.
    Abstract:
    The glucose analogue 5-thio-D-glucose (5-TG) is toxic to hypoxic cells but does not affect aerated cells. Toxicity is markedly dependent upon oxygen tension: exposure of Chinese hamster cells to 5 mM 5-TG and 50 ppm O2 (in the overlying atmosphere) results in a survival of 0.01 in six hours, whereas increasing the oxygen to 100 ppm causes the survival to increase to about 0.9. The combined effect of X rays and 5-TG is to reduce the survival of hypoxic cells to a level far below that attainable with either agent alone. Cells made hypoxic with 5 ppm O2 have 0.1 survival after three hours exposure to 5 mM 5-TG. The same cells have a 0.5 survival when given a dose of 1000 rad. When the x-irradiation is given at the end of a three-hour exposure to 5-TG, the survival is reduced to 0.0055.
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