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  • Title: Effects of prostaglandins and their methylated analogues upon human adenylate cyclase in the upper gastrointestinal tract.
    Author: Simon B, Kather H, Kommerell B.
    Journal: Digestion; 1978; 17(6):547-53. PubMed ID: 710739.
    Abstract:
    The effects of prostaglandin E2, prostaglandin A2 and their methylated analogues upon the adenylate cyclase in human gastric mucosa were studied. PG E2 and 16,16-dimethyl-PG E2 stimulated the enzyme activity to a greater degree than PG A2 and 16,16-dimethyl-PG A2. 16,16-dimethyl-PG E2 was less potent in activating the enzyme system than its parent compound. The results suggest that the more pronounced antisecretory activity of 16,16-dimethyl-PG E2 is due to its greater resistance against enzymatic degradation.
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