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  • Title: Antiallergics: 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-ones.
    Author: Yevich JP, Temple DL, Covington RR, Owens DA, Seidehamel RJ, Dungan KW.
    Journal: J Med Chem; 1982 Jul; 25(7):864-8. PubMed ID: 7108903.
    Abstract:
    A short series of the title compounds was prepared and evaluated for both antiallergic and bronchodilator activity. Members of the series exhibit good oral activity in the rat PCA test, the most potent being the parent compound, 3-(1H-tetrazol-5-yl)-4H-pyrimido[2,1-b]benzothiazol-4-one, and its 8-chloro derivative. The latter two compounds are considerably more potent than either disodium chromoglycate or theophylline as antiallergic agents and also show significant bronchodilator activity.
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