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  • Title: [Effects of furosemide on renal functions in prematures (author's transl)].
    Author: Tulassay T, Kiszel J, Machay T, Csömör S.
    Journal: Monatsschr Kinderheilkd; 1982 Jul; 130(7):541-5. PubMed ID: 7110156.
    Abstract:
    Renal effects of Furosemide were examined during the first 2-4 days of life in preterm infants suffering from respiratory distress syndrome. Administration of the drug was followed by a sevenfold increase of diuresis. This latter was a result of both a rise in sodium excretion and glomerular filtration. The possible mechanism of Furosemide induced alteration in the glomerular filtration is discussed. Furosemide also altered the hydrogen-ion excretion: both the urinary bicarbonate, the titratable acidity and the ammonium excretion increased. There was a significant rise in the net acid excretion and hydrogen clearance too. It has been found that besides its diuretic effect Furosemide might play a role in the renal hydrogen elimination.
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