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  • Title: Possible modulatory role of dynorphin on the excitation by neurotensin on the guinea pig myenteric plexus.
    Author: Huidobro-Toro JP, Way EL.
    Journal: Neurosci Lett; 1982 Jun 30; 30(3):309-14. PubMed ID: 7110637.
    Abstract:
    Dynorphin 1-13 antagonized in a concentration-dependent fashion the contractile effect of neurotensin on the isolated preparation of the guinea pig ileum myenteric plexus. The inhibitory action of dynorphin was reduced in the presence of naloxone indicating the opioid nature of this interaction. Atropine also reduced the excitatory component of the neurotensin-induced contractile response; the joint application of atropine plus dynorphin did not cause additional inhibition of the contractile effect of neurotensin.
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