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  • Title: Actions of salbutamol in late pregnancy. Serum levels of human chorionic gonadotrophin, human placental lactogen, total oestriol and progesterone in diabetic and non-diabetic women during infusion of salbutamol.
    Author: Carlström K, Lunell NO, Persson B, Wager J.
    Journal: Horm Metab Res; 1978 Sep; 10(5):434-8. PubMed ID: 711139.
    Abstract:
    The acute effects of salbutamol on the serum levels of hPL, hCG, oestriol and progesterone in diabetic and non-diabetic pregnant women in the last trimester were studied. I.V. administration of salbutamol in an increasing dose from 0 to 22.5 ug/min caused no change in hPL or hCG levels in any group. Progesterone showed a significant fall after 40 min in the diabetic group and a less pronounced, although still significant fall after 80 min in the non-diabetic group. The oestriol levels increased significantly after 40 min in the diabetic group while no significant change was noted in the non-diabetic group. It is speculated that the effects in the diabetic women might be explained by a redistribution of the available placental 5-pregnenolone due to an increased fetal conversion into oestriol. This might be due to an increased sensitivity of the adrenal cortex of these foetuses to a supposed stimulatory effect of salbutamol.
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