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  • Title: Synthesis of protected decapeptide (B21--30) of human insulin.
    Author: Naithani VK, Föhles J.
    Journal: Hoppe Seylers Z Physiol Chem; 1978 Sep; 359(9):1173-81. PubMed ID: 711158.
    Abstract:
    The synthesis of the C-terminal decapeptide derivative B21--30 of the B-chain of human insulin (benzyloxycarbonyl-gamma-t-butoxyglutamyl-arginyl-glycyl-phenylalanyl-phenylalanyl-O-t-butyltyrosyl-O-t-butylthreonyl-prolyl-Nepsilon-t-butyl-oxycarbonyllysyl-O-t-butylthreonine t-butyl ester, (XIII) by the fragment condensation of the tripeptide B21--23 with the heptapeptide B24--30 is described. Two new routes for both the tripeptide and the heptapeptide were established. A simplified method for the purification of O-t-butylthreonine t-butyl ester was developed.
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