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  • Title: Familial amyloidosis of Ostertag.
    Author: Lanham JG, Meltzer ML, De Beer FC, Hughes GR, Pepys MB.
    Journal: Q J Med; 1982; 51(201):25-32. PubMed ID: 7111672.
    Abstract:
    A 23 year old Englishman presented with keratoconjunctivitis sicca and was found to have systemic amyloidosis. Five members of his family in two generations also had non-neuropathic amyloid particularly affecting the kidneys. This conforms to the Ostertag type of hereditary amyloidosis. Amyloid deposits in the proband showed permanganate-sensitive Congophilia and positive immunofluorescence staining for P component, but were negative for amyloid A and prealbumin. These observations suggested that the fibril protein in this patient was immunochemically distinct from the amyloid fibrils characterized hitherto.
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