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  • Title: Ultrastructural changes of nuclei after treatment with mesodermal inducing substance.
    Author: Zeng MB.
    Journal: Sci Sin B; 1982 Jul; 25(7):725-9. PubMed ID: 7112079.
    Abstract:
    Ultrastructural changes occur in the nuclei of the presumptive ectoderm cells of the early gastrula of Cynops orientalis after treatment with a mesodermal inducing substance (guinea pig bone marrow extract). The large condensed chromatin masses in the nuclei of the control series are no longer found; they become more or less dispersed. The successive changes of chromatin from condensed to dispersed have been observed. And in connection with the observations on neural induction after Ca-free treatment, the transformation from heterochromatin to euchromatin as the initiation of cell differentiation has been discussed.
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