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  • Title: Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine.
    Author: Gualtieri CT, Lefler WH, Guimond M, Staye JI.
    Journal: Am J Psychiatry; 1982 Sep; 139(9):1178-80. PubMed ID: 7114312.
    Abstract:
    Of 18 mentally retarded institutionalized subjects who had received long-term, high-dose treatment primarily with thioridazine or chlorpromazine, 2 developed definite corneal and lenticular opacities and 2 had equivocal ocular changes. In view of this finding, the authors suggest that alternative treatment, including different neuroleptics, be considered with mentally retarded institutionalized subjects; when that is not possible, subjects should be given periodic evaluation, including annual slit-lamp examination.
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