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  • Title: Effects of L-alanine on ketogenesis in vitro.
    Author: Sugden MC, Watts DI.
    Journal: Biochim Biophys Acta; 1982 Aug 06; 717(2):385-6. PubMed ID: 7115774.
    Abstract:
    Alanine (5 mM) increased 14CO2 production from [1-14C]oleate by 130% and from [1-14C]butyrate by 101%. Alanine inhibited ketone-body production by 37.5% in the presence of butyrate but did not affect ketogenesis in the presence of oleate. Alanine decreased the [3-hydroxybutyrate]/[acetoacetate] ratio when either butyrate or oleate was present. The results are discussed with reference to the hypoketonaemic action of alanine in vivo.
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