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  • Title: [Analysis of the mast cell population in excitation and blockade of the anticoagulant system].
    Author: Strukov AI, Strukova SM, Khlebnikova TG, Umarova BA, Kudriashov BA.
    Journal: Biull Eksp Biol Med; 1982 Jun; 93(6):116-9. PubMed ID: 7115921.
    Abstract:
    Stimulation of the anticoagulation system with the structural analogs of alpha-thrombin, DPP-alpha-thrombin and prothrombin I having no proteolytic activity leads, as is the case with alpha-thrombin, to a decrease in the heparin content in mast cells and to a concurrent rise in the blood level of the complex compounds of heparin and blood proteins. Morphometry disclosed a substantial shift of mast cell population towards the light, heparin-free forms. In the experimental animals, the index of mast cell saturation with heparin dropped below one. Heparin release by mast cells proceeded by the merocrine secretion type, largely at the expense of granulolysis, with the cell integrity being preserved. Degranulation was effected via the strong form. Intravenous injection to the animals of alpha-thrombin in the presence of the anticoagulation system blockade with chlorpromazine produced no similar changes in the mast cell population.
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