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  • Title: Chronobiological study of pituitary adenomas and of the empty sella syndrome.
    Author: Ferrari E, Bossolo PA, Baldi F, Daguati M, Fioravanti M, Facara S.
    Journal: Chronobiologia; 1982; 9(2):241-8. PubMed ID: 7117046.
    Abstract:
    A chronobiological study was carried out in pituitary GH- and PRL-secreting adenomas and in the empty sella syndrome. The circadian rhythms of plasma GH and plasma PRL were abolished respectively in GH- and PRL-secreting pituitary tumors, and they were again detectable after selective transsphenoidal adenomectomy. In the empty sella syndrome only the chrono-organization of GH secretion was disturbed, whereas plasma PRL exhibited the usual circadian pattern. A normal circadian rhythmicity of plasma cortisol was demonstrable in the 3 groups of patients. The diagnostic significance of the chronobiological findings obtained is discussed.
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