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  • Title: Electrolyte urinary excretion in hypertensive conditions.
    Author: Natali G, Acitelli P, Cicogna S, Di Lauro G, Di Pietro M, Ruggieri M, Silberkuhl G, Spacca G, Trotta A.
    Journal: Chronobiologia; 1982; 9(2):257-65. PubMed ID: 7117048.
    Abstract:
    Daily variations of electrolyte excretion have been studied in 8 hypertensive and in 4 normotensive women by collecting urine samples every 3 h for a 48-h span. After noticing the absence of a statistically significant circadian rhythm in the hypertensive group, the Authors suggest the hypothesis that a prolonged treatment with diuretic drugs may cause kidney troubles and suppress the circadian rhythm of urinary electrolyte excretion. The Authors conclude affirming that this hypothesis needs further investigation to allow a better chronotherapy of the hypertensive disease in the future.
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