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  • Title: Gut hormone release after intestinal resection.
    Author: Besterman HS, Adrian TE, Mallinson CN, Christofides ND, Sarson DL, Pera A, Lombardo L, Modigliani R, Bloom SR.
    Journal: Gut; 1982 Oct; 23(10):854-61. PubMed ID: 7117905.
    Abstract:
    To investigate the possible role of gut and pancreatic hormones in the adaptive responses to gut resection, plasma concentrations of the circulating hormones were measured, in response to a test breakfast, in patients with either small or large intestinal resection and in healthy control subjects. In 18 patients with partial ileal resection a significant threefold rise was found in basal and postprandial levels of pancreatic polypeptide, a fourfold increase in motilin, and more than a twofold increase in gastrin and enteroglucagon levels compared with healthy controls. In contrast, nine patients with colonic resection had a threefold rise in levels of pancreatic polypeptide only. One or more of these peptides may have a role in stimulating the adaptive changes found after gut resection.
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