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  • Title: Formation of hydrotalcite in mixtures of aluminum hydroxycarbonate and magnesium hydroxide gels.
    Author: Vanderlaan RK, White JL, Hem SL.
    Journal: J Pharm Sci; 1982 Jul; 71(7):780-6. PubMed ID: 7120062.
    Abstract:
    IR and X-ray analysis demonstrate that hydrotalcite forms during the aging of aluminum hydroxycarbonate gel and magnesium hydroxide gel mixtures. The formation of hydrotalcite produces a change in the pH-stat titrigram and a sharp increase in the pH of the mixture. Hydrotalcite was noted earlier in mixtures having a high molar ratio of magnesium to aluminum, a high total gel concentration, a high initial pH, or in mixtures stored at elevated temperatures. The addition of sorbitol to the mixtures substantially delayed the appearance of hydrotalcite. Nonacid-reactive hydrotalcite formed when mixtures of chloride-containing aluminum hydroxide gel and magnesium hydroxide gel were aged.
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