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  • Title: The use of clonidine for management of opiate abstinence in a chronic pain patient.
    Author: Bakris GL, Cross PD, Hammarsten JE.
    Journal: Mayo Clin Proc; 1982 Oct; 57(10):657-60. PubMed ID: 7121072.
    Abstract:
    The use of clonidine in the management of opiate abstinence is presented in a patient dependent upon levorphanol tartrate given for chronic pain. Use of levorphanol was abruptly discontinued, and the patient was monitored for signs and symptoms of opiate withdrawal. He manifested a significant increase in pulse and blood pressure and had perspiration, agitation, and opiate-seeking behavior. Clonidine effectively abolished these signs and symptoms. The mechanism by which clonidine prevents the opiate abstinence syndrome is discussed. Clonidine is a safe and inexpensive means of achieving rapid opiate withdrawal.
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