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  • Title: Central neurohypophyseal peptide pathways: interactions with endocrine and other autonomic functions.
    Author: Pittman QJ, Veale WL, Lederis K.
    Journal: Peptides; 1982; 3(3):515-20. PubMed ID: 7122279.
    Abstract:
    Electrophysiological and pharmacological studies have been carried out in rats and rabbits to attempt to identify possible functional roles for neurohypophyseal peptides in brain. In anesthetized rats, single unit recordings and antidromic activation criteria were utilized to identify projections of the paraventricular nucleus (PVN) to neurohypophysis and to extrahypothalamic areas (amygdala or nucleus tractus solitarius). None of the cells tested innervated more than one of these areas and, when tested for their responses to haemorrhage, increased body osmolarity, or suckling of pups, only the osmotic stimulus caused increased activity in some cells projecting to amygdala or nucleus tractus solitarius. Indirect evidence as well as direct measurement by radioimmunoassay of arginine vasopressin (AVP) in brain perfusates revealed probable central release of AVP in response to stimuli known to activate pituitary secretion of this peptide. These observations raise the possibility that certain brain and pituitary peptidergic systems may function in a co-ordinated manner.
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