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  • Title: Retrospective analysis of 1500 mamma biopsies from 1951-1975. A way of self-control in pathology.
    Author: Zieger G, Stein H.
    Journal: Pathol Res Pract; 1982; 173(3):275-82. PubMed ID: 7122320.
    Abstract:
    Recently, doubts have been raised regarding the accuracy of histopathological diagnosis. For reasons of quality control, three groups of 500 mamma biopsies each, covering the consecutive periods 1951-1953, 1963-1964, 1975 were re-examined microscopically. The quota of error for material re-diagnosed as false-positive or false-negative was 0.13%. 23 pre and early malignant alterations, formerly "suspected" cases and descriptive diagnoses were considered as "borderline" cases, and re-examined separately by 3 different pathologists. In only 4 cases the suspected malignancy, i.e. the diagnosis of so-called CLIS, was not confirmed. A relative increase of unsuspected mamma biopsies became apparent in the last period of investigation, possible due to the wide range of pre-surgical examination methods used today, or to increasing clinical efforts to detect pre-malignant alterations. No shift could be established in the mastopathy-group.
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