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  • Title: Lipid peroxidation during chronic inflammation induced in rats by Freund's adjuvant: effect of vitamin E as measured by expired pentane.
    Author: Dillard CJ, Kunert KJ, Tappel AL.
    Journal: Res Commun Chem Pathol Pharmacol; 1982 Jul; 37(1):143-6. PubMed ID: 7122999.
    Abstract:
    Expired pentane, a product of omega 6-unsaturated fatty acid hydroperoxide decomposition, and foot volume were measured following injection of Freund's adjuvant into the hind feet of vitamin E-deficient rats injected 1 wk previously with either 0 or 100 mg of dl-alpha-tocopherol acetate/100 g body weight. Vitamin E inhibited pentane production after 21 and 28 days. This is the first demonstration in vivo of increased lipid peroxidation and its inhibition by vitamin E during adjuvant-induced chronic inflammation. By 28 days, foot volume was significantly less in vitamin E-injected rats (162%) than in vitamin E-deficient rats (207%).
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