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  • Title: Simultaneous quantitation of morphine and paraben preservatives in morphine injectables.
    Author: Austin KL, Mather LE.
    Journal: J Pharm Sci; 1978 Nov; 67(11):1510-1. PubMed ID: 712584.
    Abstract:
    A high-performance liquid chromatographic method for the simultaneous determination of morphine sulfate, methylparaben, and propylparaben in morphine sulfate injection was developed. A reversed-phase system, based on an octadecylsilane stationary phase, was used with a binary solvent mobile phase consisting of methanol--phosphate buffer (pH 4.0) containing methanol (5%) delivered at a constant rate (0.6:0.4 ml/min) using a two-pump system. The detector response at 254 nm was linear with the amount injected over a wide range, allowing rapid and reproducible quantitation of each component.
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